During which mitotic phase do sister chromatids separate and move toward opposite poles?

During which mitotic phase do sister chromatids separate and move toward opposite poles?

• A. Prophase
• B. Metaphase
• C. Anaphase
• D. Telophase

Answer: (C)

In mitosis, sister chromatids stay attached until the cell is ready to separate them. After the chromosomes have lined up in the middle, the cohesion holding the chromatids together is released, and the chromatids are pulled apart toward opposite poles. This separation is driven by shortening of the kinetochore microtubules and other spindle forces, so the now individual chromosomes move toward the two ends of the cell. This moment is the stage where segregation of sister chromatids occurs, followed later by the re-formation of nuclei around the separated chromosomes.

In mitosis, sister chromatids stay attached until the cell is ready to separate them. After the chromosomes have lined up in the middle, the cohesion holding the chromatids together is released, and the chromatids are pulled apart toward opposite poles. This separation is driven by shortening of the kinetochore microtubules and other spindle forces, so the now individual chromosomes move toward the two ends of the cell. This moment is the stage where segregation of sister chromatids occurs, followed later by the re-formation of nuclei around the separated chromosomes.